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It is unknown how cognitive behavioral therapy for insomnia (CBT\u2010I) impacts two hallmarks of AD progression, cognitive performance and beta\u2010amyloid (A\u03b2) burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Cognitively normal older adults with symptoms of insomnia were randomized into CBT\u2010I treatment (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0100) or control (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0100) groups. Cognitive performance was assessed at baseline, 6\u2010weeks, and 1\u2010year (1\u00a0year). A\u03b2 burden was assessed in a subsample (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      No differences were observed between groups in change in cognitive performance, including speed of information processing (mean difference, 0.017; 95% confidence interval [CI], \u22120.1036 to 0.1376; p\u00a0=\u00a00.78), executive function (\u22120.0881; 95% CI, \u22120.2945 to 0.1182;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.40), and memory (0.4068; 95% CI, \u22122.3965 to 3.2101;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.77). No group differences were observed in A\u03b2 deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CBT\u2010I did not improve cognitive performance or A\u03b2 deposition by one year. Longer follow up is needed to understand the potential impact of CBT\u2010I on AD risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION<\/jats:title>\n                    <jats:p>The study was registered on clinicaltrials.gov (NCT03954210) on 5\/17\/2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71591","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:06:48Z","timestamp":1781579208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial"],"prefix":"10.1002","volume":"22","author":[{"given":"Catherine F.","family":"Siengsukon","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Rehabilitation Science, and Athletic Training University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren K.","family":"Hand","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Rehabilitation Science, and Athletic Training University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"Department of Medicine Division of General Internal Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eryen","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Rehabilitation Science, and Athletic Training University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Glaser","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Rehabilitation Science, and Athletic Training University of Kansas Medical 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