{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:15:22Z","timestamp":1783314922586,"version":"3.54.6"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The relationship between sleep, other dementia risk factors, and dementia remains unclear. We aim to explore these associations using a two\u2010sample Mendelian randomization (MR) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We identified genetic instrumental variables for sleep characteristics from the UK Biobank and obtained summary\u2010level genetic association data for dementia outcomes, including Alzheimer\u2019s disease (AD), from the FinnGen consortium. We applied inverse\u2010variance weighted (IVW) MR to examine the associations between sleep characteristics and dementia outcomes. Multivariable MR was subsequently employed to assess the influence of additional dementia\u2010relevant factors on these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Genetic variants for insomnia, among the sleep characteristics, were associated with elevated AD risk (odds ratio [OR]\n                      <jats:sub>IVW\u00a0<\/jats:sub>\n                      =\u00a03.02, 95% confidence interval [CI]: 1.28\u20137.10,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.01). Yet this association was largely attenuated after adjusting for education and low\u2010density lipoprotein (LDL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings indicate that the association between insomnia and AD is complex and indirect, potentially operating through social\u2010behavioral factors (education) and biological pathways such as LDL cholesterol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71592","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:09:16Z","timestamp":1781579356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep and dementia: Assessing established dementia\u2010related factors using multivariable Mendelian randomization"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4572-1139","authenticated-orcid":false,"given":"Yunyun","family":"Guo","sequence":"first","affiliation":[{"name":"The Ageing Epidemiology (AGE) Research Unit School of Public Health Imperial College London  London UK"},{"name":"Institute of Science and Technology for Brain\u2010Inspired Intelligence (ISTBI) Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society, Karolinska Institute, Center for Alzheimer Research QA32  Solna Sweden"},{"name":"Department of Health Sciences the Swedish School of Sport and Health Sciences Stockholm Sweden"},{"name":"Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health University of Wisconsin  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Sindi","sequence":"additional","affiliation":[{"name":"The Ageing Epidemiology (AGE) Research Unit School of Public Health Imperial College London  London UK"},{"name":"Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society, Karolinska Institute, Center for Alzheimer Research QA32  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lefkos T","family":"Middleton","sequence":"additional","affiliation":[{"name":"The Ageing Epidemiology (AGE) Research Unit School of Public Health Imperial College London  London UK"},{"name":"Public Health Directorate Imperial College NHS Healthcare Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"The Ageing Epidemiology (AGE) Research Unit School of Public Health Imperial College London  London UK"},{"name":"Division of Clinical Geriatrics Department of Neurobiology Care Sciences and Society, Karolinska Institute, Center for Alzheimer Research QA32  Solna Sweden"},{"name":"Department of Neurology, Institute of Clinical Medicine University of Eastern Finland  Kuopio Finland"},{"name":"Theme Inflammation and Aging Karolinska University Hospital, Stockholm  Solna Sweden"},{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12635"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"issue":"12","key":"e_1_2_10_5_1","first-page":"1537","article-title":"Self\u2010reported sleep and 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