{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:50Z","timestamp":1785297950179,"version":"3.55.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Lewy body (LB) co\u2010pathology is common in Alzheimer's disease (AD), yet its in vivo impact on neurodegeneration remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We trained a 3D\u2010DenseNet on multi\u2010cohort T1\u2010weighted magnetic resonance imaging (MRI) from cognitively unimpaired individuals to estimate brain age (BA) and applied it to cognitively impaired Alzheimer's Disease Neuroimaging Initiative (ADNI) participants stratified by cerebrospinal fluid (CSF) p\u2010tau\n                      <jats:sub>181<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      (AD) and \u03b1\u2010synuclein seed amplification assay (LB) status into: AD+LB+, AD+LB\u2212, AD\u2212LB+, and AD\u2212LB\u2212. We compared baseline and longitudinal brain\u2013age gap (BAG), identified saliency\u2010derived anatomical contributors, assessed regional atrophy and cognition, and evaluated whether BAG explains LB\u2010related clinical decline within AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The model robustly captured normative aging. AD+LB+ exhibited the greatest and fastest\u2010increasing BAG, with saliency maps emphasizing regions that also showed steeper longitudinal atrophy and concordant cognitive decline, and BAG mediated a substantial portion of LB\u2010related cognitive impairment within AD+.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>LB co\u2010pathology confers an additional neurodegenerative burden in AD, underscoring the importance of combined biomarker assessment and targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71593","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:00:21Z","timestamp":1784113221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep learning\u2010based MRI analysis reveals Lewy body co\u2010pathology accelerates brain aging in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Babak","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Industrial and Systems Engineering University of Florida  Gainesville Florida USA"},{"name":"Department of Neurology University of Florida  Gainesville Florida USA"},{"name":"Magnetoencephalography (MEG) Lab The Norman Fixel Institute of Neurological Diseases University of Florida Health  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breton M.","family":"Asken","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Reisi\u2010Gahrooei","sequence":"additional","affiliation":[{"name":"Department of Industrial and Systems Engineering University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Babajani\u2010Feremi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida  Gainesville Florida USA"},{"name":"Magnetoencephalography (MEG) Lab The Norman Fixel Institute of Neurological Diseases University of Florida Health  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Australian Imaging Biomarkers and Lifestyle flagship study of 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