{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:30Z","timestamp":1788671550451,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG\u201008\u201088733"],"award-info":[{"award-number":["IIRG\u201008\u201088733"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Subclinical lower cardiac output (volume of blood pumped per minute) cross\u2010sectionally relates to smaller cerebral gray matter volumes in older adults. This study relates cardiac output to longitudinal gray matter volumes among middle\u2010aged and older adults over an 11\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Linear regression (cross\u2010sectional) and mixed effects (longitudinal) models related baseline cardiac output to gray matter volume trajectory, adjusting for demographic factors. Secondary models tested\n                      <jats:italic>cardiac output \u00d7<\/jats:italic>\n                      apolipoprotein E (\n                      <jats:italic>APOE)<\/jats:italic>\n                      \u2010\u03b54\n                      <jats:italic>status<\/jats:italic>\n                      interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Lower cardiac output related to smaller brain volumes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values\u00a0&lt;\u00a00.04) in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010\u03b54 positive participants only. In longitudinal models, baseline cardiac output interacted with\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010\u03b54 status (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.006). Lower baseline cardiac output related to greater increase in inferior lateral ventricle volume over time in\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010\u03b54 carriers (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Results suggest among\n                      <jats:italic>APOE<\/jats:italic>\n                      \u2010\u03b54 carriers, subclinical cardiac dysfunction relates to greater neurodegeneration cross\u2010sectionally and longitudinally. However, results must be interpreted with caution and replicated.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71598","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:00:35Z","timestamp":1785841235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower cardiac output is a risk factor for faster cerebral atrophy over a 11\u2010year follow\u2010up period in\n                    <i>APOE\u2010<\/i>\n                    \u03b54 carriers"],"prefix":"10.1002","volume":"22","author":[{"given":"Elizabeth E.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Neurology Mass General Brigham  Boston Massachusetts USA"},{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee 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Nashville Tennessee USA"},{"name":"Department of Biostatistics Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Alzheimer's Disease Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt Translational and Clinical Cardiovascular Research Center Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly R.","family":"Pechman","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Vanderbilt Alzheimer's Disease Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Gifford","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett A.","family":"Landman","sequence":"additional","affiliation":[{"name":"Vanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Vanderbilt Alzheimer's Disease Research Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center, TenVnessee  Nashville USA"},{"name":"Department of Electrical Engineering and Computer Science Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy 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