{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:47:05Z","timestamp":1791586025184,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Positron emission tomography (PET) is a valuable tool for assessing tau pathology in Alzheimer's disease (AD), but it is not widely accessible. Clarifying the relationship between fluid tau species and tau PET in AD may allow for the identification of fluid biomarkers that could serve as more accessible surrogates for tau PET.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Cerebrospinal fluid (CSF) and plasma tau species levels were assessed across prodromal to moderate AD subjects (CSF:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a053, plasma:\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0181) via immunoassays and liquid chromatography\u2010mass spectrometry. Fluid measures were correlated with [\n                      <jats:sup>18<\/jats:sup>\n                      F]GTP1 tau PET at baseline for head\u2010to\u2010head comparisons across analytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      CSF C2N\u2010eMTBR\u2010tau243, tau phosphorylated at threonine 205 (p\u2010tau205), p\u2010tau217, and a peptide from the tau\u2010441 microtubule\u2010binding region (MTBR) (MTBR\/243\u2010254) exhibited the highest correlations with [\n                      <jats:sup>18<\/jats:sup>\n                      F]GTP1 standardized uptake value ratio. Plasma p\u2010tau181 and p\u2010tau217 demonstrated correlation rankings with tau PET similar to those observed with corresponding CSF analytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CSF C2N\u2010eMTBR\u2010tau243, MTBR\/243\u2010254, p\u2010tau205, and p\u2010tau217 demonstrated comparable strong correlations with tau PET. These findings may guide future development of plasma biomarker surrogates for tau PET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71604","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T02:55:55Z","timestamp":1782788155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Julie","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Translational Medicine OMNI Genentech Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Olafson","sequence":"additional","affiliation":[{"name":"Imaging Data Insights, Research &amp; Early Development Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Data and Statistical Sciences Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Casavant","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Operations Diagnostics Technology Innovation Genentech Inc  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Schauer","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine OMNI Genentech Inc.  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Hoffmann\u2010La Roche AG  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Meyer","sequence":"additional","affiliation":[{"name":"C2N Diagnostics, LLC  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip B.","family":"Verghese","sequence":"additional","affiliation":[{"name":"C2N Diagnostics, LLC  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venky","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"C2N Diagnostics, LLC  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"West","sequence":"additional","affiliation":[{"name":"C2N Diagnostics, LLC  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B.","family":"Braunstein","sequence":"additional","affiliation":[{"name":"C2N Diagnostics, LLC  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Biever","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine OMNI Genentech Inc.  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