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Adherence was similar between groups with no serious adverse effects. Blood NAD\n                      <jats:sup>+<\/jats:sup>\n                      increased twofold in the NR group. There were no improvements in cognitive function (primary outcome), total CBF, or blood pressure (secondary outcomes). Exploratory analyses revealed potential increases in regional CBF, particularly in the hippocampus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      NR effectively raises NAD\n                      <jats:sup>+<\/jats:sup>\n                      in people with MCI but does not improve cognitive function, total CBF, or blood pressure over 12\u00a0weeks. Future studies should investigate regional effects on CBF over longer treatment durations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71605","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:00:21Z","timestamp":1784631621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A phase\u2010II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-2948","authenticated-orcid":false,"given":"Christopher R.","family":"Martens","sequence":"first","affiliation":[{"name":"Department of Kinesiology &amp; Applied Physiology University of Delaware  Newark Delaware USA"},{"name":"Delaware Center for Cognitive Aging Research University of Delaware  Newark Delaware 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