{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:35:58Z","timestamp":1790699758204,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["WE.03\u20102024\u201027"],"award-info":[{"award-number":["WE.03\u20102024\u201027"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Early Alzheimer's disease (AD) involves subtle cortical changes that may precede atrophy. Magnetic resonance imaging (MRI) microstructural markers may detect earlier pathology than classical morphometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed cross\u2010sectional MRI and amyloid\u2010\u03b2 (A\u03b2) positron emission tomography (PET) data from 1323 non\u2010demented AMYPAD participants. Cortical volume, thickness, gray\u2013white matter contrast (GWC), and mean diffusivity (MD) were related to global A\u03b2 burden and estimated time to A\u03b2\u2010positivity using regression, correlation, and change\u2010point analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Microstructural measures showed stronger age associations than macrostructural measures, whereas all measures were unaffected by apolipoprotein E (\n                      <jats:italic>APOE)<\/jats:italic>\n                      \u2010\u03b54 carriership. GWC and MD showed minimal overlap with volume and thickness. Higher A\u03b2 burden was most strongly associated with reduced GWC and cortical thinning. Change\u2010point analyses showed GWC alterations preceded A\u03b2\u2010positivity by several years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Cortical microstructural MRI, particularly GWC, changes earlier than atrophy and may serve as an early in vivo marker of AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71609","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:46:59Z","timestamp":1782272819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cortical gray\u2013white matter contrast alterations precede amyloid\u2010\u03b2 positivity and macrostructural changes in older adults without dementia"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9003-4588","authenticated-orcid":false,"given":"Leonard","family":"Pieperhoff","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Brain imaging Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9756-881X","authenticated-orcid":false,"given":"Luigi","family":"Lorenzini","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Brain imaging Amsterdam Neuroscience  Amsterdam the Netherlands"},{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-4136","authenticated-orcid":false,"given":"Francisco","family":"Almeida","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS) School of Medicine, University of Minho  Braga Portugal"},{"name":"Department of Neuroradiology Hospital de Braga, ULS Braga  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-4746","authenticated-orcid":false,"given":"Mario","family":"Tranfa","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Brain imaging Amsterdam Neuroscience  Amsterdam the Netherlands"},{"name":"Department of Anatomy and Neurosciences Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Neurodegeneration Amsterdam Neuroscience  Amsterdam the Netherlands"},{"name":"Department of Advanced Biomedical Sciences University of Naples \u201cFederico II\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-7530","authenticated-orcid":false,"given":"Ariane","family":"Bollack","sequence":"additional","affiliation":[{"name":"GE HealthCare  Amersham UK"},{"name":"Department of Medical Physics and Biomedical Engineering UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-6250","authenticated-orcid":false,"given":"Prithvi","family":"Arunachalam","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Brain imaging Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-7426","authenticated-orcid":false,"given":"Federico","family":"Masserini","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam University Medical Center  Amsterdam the Netherlands"},{"name":"Brain imaging Amsterdam Neuroscience  Amsterdam the Netherlands"},{"name":"\u201cL. 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