{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:20Z","timestamp":1785297920396,"version":"3.55.0"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Adherence to treatment guidelines for agitation in dementia is suboptimal and inconsistent. We designed and evaluated an Integrated Care Pathway (ICP) for the management of agitation in dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This was a double\u2010blind randomized controlled trial at 12 inpatient units and long\u2010term\u2010care homes (LTCHs) across Canada. Participants were randomized 1:1 to the ICP or treatment\u2010as\u2010usual (TAU). Primary outcomes were Cohen Mansfield Agitation Inventory (CMAI) and psychotropic polypharmacy at 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We randomized 185 participants (93 inpatients, 92 in LTCHs). For CMAI, there were no significant time\u2010by\u2010treatment\u2010group interactions among inpatients (F\n                      <jats:sub>4, 299.3\u00a0<\/jats:sub>\n                      =\u00a01.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.14) or LTCH residents (F\n                      <jats:sub>4, 296.0\u00a0<\/jats:sub>\n                      =\u00a00.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.48). For polypharmacy, there were significant time\u2010by\u2010treatmentgroup interactions among both inpatients (=\u00a015.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032) and LTCH residents (=\u00a030.0,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), with lower rates of polypharmacy in the ICP group at certain time points, but not at week 12.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Standardizing care for agitation in dementia may result in lesser polypharmacy without affecting efficacy. Future studies should assess the ICP in the broader community and outpatients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71610","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:00:16Z","timestamp":1785150016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Standardizing care for agitation in Alzheimer's disease, results from a randomized controlled trial of an integrated care pathway versus usual care \u2013 the StaN trial"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-353X","authenticated-orcid":false,"given":"Sanjeev","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Psychiatry Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Division of Geriatric Psychiatry Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Toronto Dementia 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