{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:13:03Z","timestamp":1793070783571,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","award":["WJP\u2010150643"],"award-info":[{"award-number":["WJP\u2010150643"]}],"id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","award":["CCNA 049\u201004"],"award-info":[{"award-number":["CCNA 049\u201004"]}],"id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","award":["CNA\u2010163902"],"award-info":[{"award-number":["CNA\u2010163902"]}],"id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Women make up two\u2010thirds of people with Alzheimer's disease (AD). Research has focused on biological explanations for this sex difference, while contributions of psychosocial risk factors are less well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We examined sex differences in the effects of adverse childhood experiences (ACEs) on late\u2010life cognition in groups along a continuum of AD risk: cognitively unimpaired controls (CU;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0128), subjective cognitive decline (SCD;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0113), mild cognitive impairment (MCI;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0241), and AD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a077), from the Canadian Consortium on Neurodegeneration in Aging Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS\u2010ND) study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Women reported more ACEs than men. There were negative associations between ACEs and hippocampal and prefrontal cortical volumes in CU men and prefrontal volumes in men with SCD. In MCI, ACEs were linked to poorer executive function and associative memory in women. No ACE\u2010related effects were found in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>ACEs may have enduring effects on late\u2010life cognition that differ between men and women and vary by cognitive status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71612","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T08:53:41Z","timestamp":1782118421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex differences in the association of adverse childhood experiences with brain and cognition along a continuum of risk for Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Mateja","family":"Perovi\u0107","sequence":"first","affiliation":[{"name":"Department of Psychology University of Toronto  Toronto Canada"},{"name":"Centre for Addiction and Mental Health  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Psychology Concordia University  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Einstein","sequence":"additional","affiliation":[{"name":"Tema Genus Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"Rotman Research Institute Baycrest Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Alzheimer's Association[Internet]. [cited2025].Women and Alzheimer's | Alzheimer's Association. Available from:https:\/\/www.alz.org\/alzheimers\u2010dementia\/what\u2010is\u2010alzheimers\/women\u2010and\u2010alzheimer\u2010s"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3601"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2012.712676"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.685"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.04.019"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000276984.19542.e6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.045211"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(95)02800-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.016.2009"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41155-018-0107-y"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.03.004"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.06.016"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.03.005"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.011"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.05.008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20740"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnac041"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.17.1652"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610216001800"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2019.1708618"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S68226"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-015-1024-3"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01388.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01138-w"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116984"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31823efc6c"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2019.27"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2018.00085"},{"issue":"1","key":"e_1_2_11_33_1","first-page":"179","article-title":"The comprehensive assessment of neurodegeneration and Dementia (COMPASS\u2010ND) study neuropsychology battery of the Canadian consortium on neurodegeneration in aging (CCNA): battery development and description","volume":"45","author":"Phillips NA","year":"2026","journal-title":"Can J Aging Rev Can Vieil"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26197"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.3.328-b"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141470"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617709990956"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62604-z"},{"key":"e_1_2_11_40_1","doi-asserted-by":"crossref","unstructured":"DelisDC EdithK KramerJH Delis\u2010Kaplan Executive Function System[Internet].American Psychological Association(APA);2001[cited 2025 May 18]. Available from:https:\/\/cir.nii.ac.jp\/crid\/1883679868048885888","DOI":"10.1037\/t15082-000"},{"key":"e_1_2_11_41_1","doi-asserted-by":"crossref","unstructured":"WechslerD Wechsler memory scale.San Antonio TX US:Psychological Corporation;1945. (Wechsler memory scale).","DOI":"10.1037\/t27207-000"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2007.119826"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-017-0632-2"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170700102X"},{"issue":"1","key":"e_1_2_11_45_1","first-page":"21","article-title":"Quality of life in Alzheimer's disease: patient and caregiver reports","volume":"5","author":"Logsdon RG","year":"1999","journal-title":"J Ment Health Aging"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(91)90150-B"},{"issue":"4","key":"e_1_2_11_47_1","first-page":"709","article-title":"Geriatric depression scale","volume":"24","author":"Yesavage JA","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.32"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.05.008"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.01.006"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535978"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(03)00013-7"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0854-y"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.136903"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2020.100879"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/amp0000768"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.21833"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2020.1832203"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2020.104485"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121246109"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1037\/tra0000356"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/07334648211058718"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwab019"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20200064"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/2331205X.2019.1581447"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1037\/0000143-008"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0002-z"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.07.067"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac500"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318246eb10"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003142"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2007.12.009"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:06:24Z","timestamp":1782309984000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/alz.71612"],"URL":"https:\/\/doi.org\/10.1002\/alz.71612","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71612"}}