{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:48:03Z","timestamp":1782312483331,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker for Alzheimer's disease (AD) progression in clinical studies, yet the role of brain GFAP in AD\/AD\u2010related dementias (ADRD) pathologies and cognitive decline remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>GFAP burden from CA1\u2010subiculum of the hippocampus were quantified. Regression and mixed\u2010effect models, adjusting for demographics and other brain pathologies examined associations between hippocampal GFAP and AD\/ADRD pathologies and separately with Alzheimer's dementia and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy neuropathologic changes (LATE\u2010NC), hippocampal sclerosis of aging (HS\u2010A), and neurofibrillary tangle density (but not amyloid\u2010beta) were associated with GFAP burden. Hippocampal GFAP was associated with increased odds of Alzheimer's dementia and faster decline in global cognition, episodic memory, semantic memory, and perceptual speed. LATE\u2010NC and tangles explained some but not all the association between hippocampal GFAP and cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>GFAP burden in the hippocampus is related to LATE\u2010NC and tangles but may also be an independent contributor to cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71613","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T02:53:07Z","timestamp":1781751187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal GFAP in aging: Associations with AD and LATE\u2010NC pathologies and cognitive decline in older adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Sonal","family":"Agrawal","sequence":"first","affiliation":[{"name":"Rush Alzheimer's Disease Center Rush 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