{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:41Z","timestamp":1785297941170,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Whether cardiovascular\u2013kidney\u2013metabolic (CKM) syndrome stage modifies cognitive benefits of intensive blood pressure (BP) control remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This post hoc analysis of \u200cSystolic Blood Pressure Intervention Trial \u2013 Memory and Cognition in Decreased Hypertension (SPRINT MIND) classified participants into non\u2010advanced CKM (Stage 2,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05,632) and advanced CKM (Stages 3\u20134,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02,931). The primary outcome was probable dementia; secondary outcomes included mild cognitive impairment (MCI) and probable dementia or MCI composite. Treatment effects were evaluated using Cox models and generalized linear models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In non\u2010advanced CKM, intensive BP control reduced risks of probable dementia (hazard ratio [HR] 0.62, 95% confidence interval [CI] 0.46\u20130.85) and composite outcome (HR 0.74, 95% CI 0.62\u20130.89). No benefit was observed in advanced CKM (probable dementia: HR 1.15; composite: HR 0.97). Significant interactions between treatment and CKM stage were observed for probable dementia (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Among patients with hypertension and non\u2010advanced CKM syndrome, intensive BP control was associated with lower risk of probable dementia, whereas no such benefit was observed in advanced CKM (see Graphical Abstract).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71623","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:11:28Z","timestamp":1782551488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular\u2013kidney\u2013metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhongxiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The Second Xiangya Hospital Central South University  Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Capital Medical University Affiliated Anzhen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neuroepidemiology Beijing Neurosurgical Institute, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoyang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Computing Sciences University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhe","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology Beijing Aerospace General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Academician Workstation Changsha Medical University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Practice Beijing Nuclear Industry Hospital  Beijing 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