{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:49Z","timestamp":1785297949204,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG053952"],"award-info":[{"award-number":["R01 AG053952"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R35 AG072307"],"award-info":[{"award-number":["R35 AG072307"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL082610"],"award-info":[{"award-number":["T32HL082610"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Poor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline. We tested whether poor sleep promotes neurodegeneration and cognitive deficits via ChP dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Baseline magnetic resonance imaging (MRI) \u2010derived ChP, hippocampal, ventricular, and gray matter volumes from 635 cognitively unimpaired older adults were analyzed. Sleep was measured with the Pittsburgh Sleep Quality Index and accelerometry. Confirmatory factor analysis generated cognitive domain scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Poorer self\u2010reported sleep quality was associated with greater ChP volume, while accelerometry measures were not. Greater ChP volume was associated with smaller hippocampi and gray matter, and larger ventricles. ChP mediated relationships between sleep quality and hippocampal and ventricular volumes. Gray matter mediated associations between ChP and cognitive domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Altered ChP morphology may link poor sleep to neurodegeneration and cognitive decline in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71627","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:26:35Z","timestamp":1783398395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-0507","authenticated-orcid":false,"given":"Miranda G.","family":"Chappel\u2010Farley","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey R.","family":"Sewell","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"},{"name":"Centre for Healthy Ageing Health Futures Institute Murdoch University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey M.","family":"Collins","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Molina\u2010Hidalgo","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivangi","family":"Jain","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Solis\u2010Urra","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"},{"name":"Faculty of Education and Social Sciences Universidad Andres Bello  Vi\u00f1a del Mar Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Oberlin","sequence":"additional","affiliation":[{"name":"Neuroscience AdventHealth Research Institute  Orlando Florida USA"},{"name":"Department of Psychiatry Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Grove","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur F.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"McAuley","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Department of Health and Kinesiology University of Illinois at Urbana Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana Champaign  Urbana Illinois USA"},{"name":"Department of Neurology University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Hillman","sequence":"additional","affiliation":[{"name":"Department of Psychology Northeastern University  Boston Massachusetts USA"},{"name":"Institute for Cognitive and Brain Health Northeastern University  Boston Massachusetts USA"},{"name":"Department of Physical Therapy, Movement, &amp; Rehabilitation Sciences Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Vidoni","sequence":"additional","affiliation":[{"name":"Department of Psychology Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley P.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Department of Bioengineering, Grainger College of Engineering University of Illinois Urbana Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Marsland","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:37:17Z","timestamp":1785296237000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/alz.71627"],"URL":"https:\/\/doi.org\/10.1002\/alz.71627","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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