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This study aimed to identify language markers for specific neuropathologies using both standard clinical tests and narrative speech analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed data from 82 autopsy\u2010confirmed PPA cases, including Alzheimer's disease (AD), transactive DNA\u2010binding protein 43 (TDP\u201043) type C (TDP\u2010C), Pick's disease, and 4R\u2010tauopathies (progressive supranuclear palsy\/ cortico\u2010basal degeneration (PSP\/CBD). Linear mixed\u2010effects regression was used to analyze performance on standardized aphasia tests and narrative speech variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>TDP\u2010C showed severe semantic deficits but high fluency, while AD was distinguished by impaired repetition. Narrative analysis differentiated 4R\u2010Tauopathies: CBD patients demonstrated significantly poorer syntax and irregular verb inflection than PSP or Pick's, whereas PSP showed the lowest fluency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>While standard tests effectively capture lexical\u2010semantic features in AD and TDP\u2010C, narrative measures reveal subtle grammatical and fluency differences critical for distinguishing specific tauopathies. This study outlines a more robust approach for predicting underlying pathology in PPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71633","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:01:27Z","timestamp":1783396887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuropathology\u2010specific language features in primary progressive aphasia"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-330X","authenticated-orcid":false,"given":"Jane","family":"Stocks","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University  Chicago Illinois 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