{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:04:23Z","timestamp":1785297863792,"version":"3.55.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053504"],"award-info":[{"award-number":["R01AG053504"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      Women carrying the apolipoprotein E4 (\n                      <jats:italic>APOE4)<\/jats:italic>\n                      allele have a greater risk of Alzheimer's disease (AD) from ages 65\u201075 years compared to men, yet the effects of\n                      <jats:italic>APOE4<\/jats:italic>\n                      on cognitive and neuroimaging outcomes among midlife women remain poorly understood. We investigated\n                      <jats:italic>APOE4\u2010<\/jats:italic>\n                      related differences in memory\u2010based functional neuroimaging outcomes in cognitively normal, midlife postmenopausal women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We measured blood\u2010oxygen\u2010level\u2010dependent activation and hippocampal functional connectivity during a functional magnetic resonance imaging verbal encoding task. Linear regression models tested\n                      <jats:italic>APOE4<\/jats:italic>\n                      differences (carriers vs. non\u2010carriers) and associations of neuroimaging indices with verbal memory measures and plasma AD biomarkers, adjusting for age, race, and education.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among 145 women from MsBrain,\n                      <jats:italic>APOE4<\/jats:italic>\n                      carriers and non\u2010carriers did not differ in verbal memory performance or AD biomarker levels. During verbal encoding,\n                      <jats:italic>APOE4<\/jats:italic>\n                      carriers had significantly decreased activation and hippocampal functional connectivity in several regions compared to non\u2010carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      <jats:italic>APOE4<\/jats:italic>\n                      \u2010related functional brain differences are present by midlife in postmenopausal women.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71635","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:12:57Z","timestamp":1782551577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence of\n                    <i>APOE4\u2010<\/i>\n                    related brain vulnerabilities in verbal memory systems in midlife women"],"prefix":"10.1002","volume":"22","author":[{"given":"Katrina A.","family":"Wugalter","sequence":"first","affiliation":[{"name":"Department of Psychology University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Departments of Epidemiology Psychology and Clinical and Translational Science University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Departments of Bioengineering and Clinical and Translational Science University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Ilyas","family":"Kamboh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Departments of Human Genetics and Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline M.","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Illinois Chicago  Chicago Illinois USA"},{"name":"Departments of Psychiatry and Obstetrics &amp; Gynecology University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.2188"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0305\u201012.2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5185"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24135"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1297.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13209"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003\u20101707"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18\u201009\u201003180.1998"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20101746"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20104\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.04.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"GoveasJS XieC ChenG et\u00a0al.Functional Network Endophenotypes Unravel the Effects of Apolipoprotein E Epsilon 4 in Middle\u2010Aged Adults. 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