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Spatial transcriptomic imaging and pathway analysis of differentially expressed genes (DEGs) within myeloid cells demonstrate down\u2010regulated disease\u2010associated (DAM) pathways involving A\u03b2 clearance, response to lipids, and macrophage activation within infected 5xFAD brains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>JHMV encephalitis induces dysregulated gene expression and myeloid cell responses to A\u03b2 plaque burden in 5xFAD mouse brains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71637","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:09:33Z","timestamp":1782529773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute viral encephalitis impacts dense\u2010core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques"],"prefix":"10.1002","volume":"22","author":[{"given":"Dominic Ibarra","family":"Javonillo","sequence":"first","affiliation":[{"name":"Department of Neurobiology &amp; Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Neurobiology &amp; Behavior University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellie","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Deparment of Molecular Biology &amp; Biochemistry University of California  Irvine California 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