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Open\u2010field behavior was assessed baseline and 3 and 6 months post\u2010transduction, followed by neuropathology and neuroinflammation analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Post\u2010plaque induction in amyloid mice increased asyn\/tau total and phosphorylated levels and exacerbated amyloid\u2010related hyperlocomotion\/anxiety. Pre\u2010plaque induction produced robust phosphorylated pathologies irrespective of amyloid, while causing similar amyloid\u2010dependent behavioral synergy. Tau pathology drove LGALS3\n                      <jats:sup>+<\/jats:sup>\n                      inflammatory glial responses in white\u2010matter fibers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Amyloid context gates vulnerability, with certain synergies manifesting across stages. White\u2010matter gliosis is a novel mechanism of tau\n                      <jats:sup>A152T<\/jats:sup>\n                      risk. Together, our data argue for the development of stage\u2010aware, multitarget interventions and biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71639","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:08:34Z","timestamp":1783062514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amyloid exacerbates tau and alpha\u2010synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-3430","authenticated-orcid":false,"given":"Benjamin E.","family":"Rabichow","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program Mayo Clinic Graduate School of Biomedical Sciences  Phoenix Arizona USA"},{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacey","family":"Nixon","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E.","family":"Tallant","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelin A.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Nascari","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Hudson","family":"Barnett","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program Mayo Clinic Graduate School of Biomedical Sciences  Phoenix Arizona USA"},{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashali","family":"Massa","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program Mayo Clinic Graduate School of Biomedical Sciences  Phoenix Arizona USA"},{"name":"Department of Neuroscience Mayo Clinic  Phoenix Arizona USA"},{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Fryer","sequence":"additional","affiliation":[{"name":"Center for Accelerated Nanotherapeutics Translational Genomics Research 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