{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:24Z","timestamp":1793208864445,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Iatrogenic transmission of amyloid beta can cause cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), but the relationship between these phenotypes is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrospectively analyzed standardized neuropsychological and neuroimaging data from 11 patients with iatrogenic CAA (iCAA). Brain MRI was assessed for medial temporal lobe atrophy (MTA), the posterior atrophy score for parietal atrophy, and global cortical atrophy (GCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>All patients (mean age 42 \u00b1 8.3 years) had childhood neurosurgery; 91% had confirmed cadaveric dura exposure. Six patients (55%) presented with intracerebral hemorrhage, and none showed MTA, parietal atrophy, or GCA at presentation. Over a median 5\u2010year follow\u2010up, 8\/11 (73%) developed atrophy on at least one score, moderate to severe in three patients. Cognitive impairment was present in 9\/11 (82%) at a median 3\u2010year follow\u2010up. AD was confirmed histopathologically in 2\/4 (50%) examined cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Progressive brain atrophy and cognitive impairment are common in iCAA, suggesting frequent co\u2010existing neurodegeneration and possible AD pathology. Vigilance for cognitive decline may enable earlier identification and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71640","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:11:04Z","timestamp":1782900664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-2488","authenticated-orcid":false,"given":"Larysa","family":"Panteleienko","sequence":"first","affiliation":[{"name":"Department of Translational Neuroscience and Stroke Stroke Research Centre, UCL Queen Square Institute of Neurology  London UK"},{"name":"Deptartment of Neurology Bogomolets National Medical University  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Institute of Prion Diseases MRC Prion Unit at UCL  London UK"},{"name":"National Prion Clinic, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dermot","family":"Mallon","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"},{"name":"Lysholm Department of Neuroradiology National Hospital for Neurology and Neurosurgery  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Chan","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Fandler\u2010H\u00f6fler","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience and Stroke Stroke Research Centre, UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Oliver","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Harvey","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Jaunmuktane","sequence":"additional","affiliation":[{"name":"Division of Neuropathology National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Clinical and Movement Neurosciences and Queen Square Brain Bank for Neurological Disorders Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Collinge","sequence":"additional","affiliation":[{"name":"Institute of Prion Diseases MRC Prion Unit at UCL  London UK"},{"name":"National Prion Clinic, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Werring","sequence":"additional","affiliation":[{"name":"Department of Translational Neuroscience and Stroke 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