{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:31Z","timestamp":1793208871554,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571611"],"award-info":[{"award-number":["82571611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401680"],"award-info":[{"award-number":["82401680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH212"],"award-info":[{"award-number":["ZR2023QH212"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QH206"],"award-info":[{"award-number":["ZR2023QH206"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2024CXGC010603"],"award-info":[{"award-number":["2024CXGC010603"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC2118Z"],"award-info":[{"award-number":["ZR2025QC2118Z"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Emerging evidence has linked chronic diseases with structural brain measures; however, the relationship between multimorbidity patterns and brain\u2013age gap is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This community\u2010based study involved 1151 dementia\u2010free older adults in Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND\u2010China). Multimorbidity was defined as coexistence of two or more chronic diseases. Hierarchical cluster analysis was used to identify five patterns of multimorbidity. We additionally defined cardiometabolic multimorbidity as coexistence of two or more cardiometabolic diseases. The predicted brain age was estimated using DeepBrainNet. Data were analyzed using linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The number of chronic diseases, multimorbidity, and cardiometabolic multimorbidity were significantly associated with larger brain\u2013age gap (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The multimorbidity clusters comprising cerebrovascular disease and metabolic disorders or biliary tract diseases, dorsopathies, anemia, and hearing problems were significantly correlated with larger brain\u2013age gap (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The overall burden and cardiometabolic pattern of multimorbidity are associated with advanced brain aging in dementia\u2010free older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71647","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:20:36Z","timestamp":1782962436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multimorbidity burden and patterns associated with DeepBrainNet\u2010derived brain\u2013age gap in dementia\u2010free older adults: A community\u2010based study"],"prefix":"10.1002","volume":"22","author":[{"given":"Xinyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital, Shandong University  Jinan Shandong P.R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dige","family":"Ai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Department of Neurology Ministry of Education Shandong Provincial Hospital affiliated to Shandong First Medical University  Jinan Shandong P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurology Shandong Provincial Hospital, Shandong University  Jinan Shandong P.R. 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