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Clinical and cognitive testing, sleep\/activity measures (PSQI, diaries, wearables), high\u2010resolution T1, and resting\u2010state functional magnetic resonance imaging scans were acquired. Hippocampal and amygdala subfield volumes and hippocampus\u2212amygdala connectivity were analyzed longitudinally.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After the 6\u2010month intervention, the intervention group showed increased hippocampus\u2013amygdala connectivity and attenuated subfield atrophy. One year later, both groups progressed in cognitive decline and hippocampal atrophy. Hippocampal and amygdalar volumes and connectivity were associated with sleep parameters as well as activity and cognitive parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Exercise was associated with short\u2010term MTL preservation and network reorganization linked to sleep and activity, supporting continuous physical activity for lasting benefits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71651","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:41:29Z","timestamp":1787647289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal effects of physical activity on sleep in association with hippocampal\u2010amygdala subfield structure and functional connectivity in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-0750","authenticated-orcid":false,"given":"Ravi","family":"Dadsena","sequence":"first","affiliation":[{"name":"Centre for Dementia and Prevention Aachen (ZDPA) Department of Neurology RWTH Aachen University  Aachen Germany"},{"name":"JARA Brain Institute Translational Neuroscience Research Centre J\u00fclich and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Centre for Dementia and Prevention Aachen (ZDPA) Department of Neurology RWTH Aachen University  Aachen Germany"},{"name":"JARA Brain Institute Translational Neuroscience Research Centre J\u00fclich and RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"David","sequence":"additional","affiliation":[{"name":"Centre for Dementia and 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