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We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      PET was performed with a fibrin\u2010binding probe (FBP) in TgCRND8 and wild\u2010type mice using a zirconium\u201089\u2013radiolabeled and a click\u2010chemistry pre\u2010targeted gallium\u201068 radiotracer. Platelet content was assessed in\n                      <jats:italic>post mortem<\/jats:italic>\n                      brain tissue from AD patients and TgCRND8 mice, and evaluated by PET using a CD41 pre\u2010targeted gallium\u201068 nanoradiotracer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cerebral FBP uptake differentiated TgCRND8 from wild\u2010type mice, particularly\n                      <jats:italic>ex vivo<\/jats:italic>\n                      and with advancing age. Cerebral fibrin burden correlated with platelet content in AD patients, and elevated cerebral platelet burden in TgCRND8 mice was confirmed in\n                      <jats:italic>post mortem<\/jats:italic>\n                      tissue and in vivo by PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings support PET\u2010based detection of AD\u2010associated cerebral microthrombi and the development of imaging biomarkers to stratify AD patients by procoagulant status and inform personalized therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71652","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:16:54Z","timestamp":1783063014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-8095","authenticated-orcid":false,"given":"Carlos","family":"Ceron","sequence":"first","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), C. 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