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Compared to controls, baseline samples from patients with AD showed altered frequencies and functions of na\u00efve and unswitched memory (UswM) B cells. Lecanemab treatment corrected the abnormal na\u00efve and UswM B cell proportions and rebuilt their functional homeostasis by alleviating chronic inflammation and reversing the dysregulation of key pathways including immune response, NF\u2010\u03baB, RAGE, and cell adhesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings uncover a novel peripheral immunomodulatory mechanism of Lecanemab, offering new insights into AD therapeutics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71655","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:34:26Z","timestamp":1783532066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lecanemab treatment improves B cell subpopulation immune homeostasis in patients with Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"given":"Yutong","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Neurology Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Institute of Clinical Neurology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering Medicine Beihang University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Huang","sequence":"additional","affiliation":[{"name":"The School of Public Health Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and 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