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Outcomes were collected at baseline, 2\u20137 days, 6\u00a0weeks, and 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient\u2010reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70\u201375 year), whereas teleconference reduced depressive symptoms more for younger participants (60\u201364 years) and videoconference increased knowledge for non\u2010White participants as compared to White participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      These data suggest that both telephone and videoconference are reasonable options for disclosure of\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71658","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:39:21Z","timestamp":1785213561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CONNECT4\n                    <i>APOE<\/i>\n                    : A randomized trial of telephone versus real\u2010time two\u2010way videoconference for disclosure of\n                    <i>APOE<\/i>\n                    genotype results in cognitively unimpaired adults"],"prefix":"10.1002","volume":"22","author":[{"given":"Elisabeth McCarty","family":"Wood","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Langbaum","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"Egleston","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Ofidis","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Cacioppo","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M.","family":"Langlois","sequence":"additional","affiliation":[{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\u2010Oncology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott Y. 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