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It is unclear whether age can differentiate across AD stages (amyloid positivity, tau positivity, mild cognitive impairment [MCI], dementia).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS<\/jats:bold>\n                    : Using data from the Alzheimer's Biomarker Consortium\u2013Down Syndrome, we analyzed how well age differentiated stage using receiver operating characteristic curves. We compared areas under the curve (AUC) for age to AUCs for imaging, biofluid, cognitive, motor, and behavioral variables.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS<\/jats:bold>\n                    : Sample varied by stage and variable. Up to 148 variables and 461 participants were analyzed. Age effectively differentiated amyloid positivity, tau positivity, and MCI (AUCs\u00a0&gt;\u00a00.85) but poorly discriminated MCI from dementia (0.588). No variable was better than age in distinguishing stages, except for MCI\/dementia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>DISCUSSION<\/jats:bold>\n                    : Our results show that age alone is effective at staging DS AD. Age is the most reliable correlate of amyloid, tau status, and cognitive impairment in DS and could screen for future clinical trials.\n                  <\/jats:p>","DOI":"10.1002\/alz.71661","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:24:45Z","timestamp":1784085885000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age predicts Alzheimer's in Down syndrome better than MRI, plasma, or cognition"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-1400","authenticated-orcid":false,"given":"James T.","family":"Kennedy","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie K.","family":"Wisch","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University School of Medicine in St. Louis  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Handen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigan","family":"Hartley","sequence":"additional","affiliation":[{"name":"Waisman Center University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Department of Human Development &amp; Family Studies University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University  New York New York USA"},{"name":"Gertrude H. 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