{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:47Z","timestamp":1793208887033,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Patients with sporadic frontotemporal dementia (FTD) display changes in metabolism and body composition. No studies have examined body composition changes in pre\u2010symptomatic\n                      <jats:italic>C9orf72<\/jats:italic>\n                      mutation carriers\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Asymptomatic\n                      <jats:italic>C9orf72<\/jats:italic>\n                      expansion carriers between 2017 and 2022 (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a028 non\u2010carriers, 16 expansion\u2010positive), underwent dual\u2010energy X\u2010ray absorptiometry (measurement of changes in body composition) and brain magnetic resonance imaging (MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Changes in body composition were identified in the\n                      <jats:italic>C9orf72<\/jats:italic>\n                      expansion carrier group compared to non\u2010carrier group (average 11\u201312 years prior to onset): lower android\u2010to\u2010gynoid ratio (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), and visceral adipose tissue area (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.010). Lower android\u2010to\u2010gynoid ratio and lean mass were associated with lower volumes across the cortex, subcortex, and thalamus.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      The current study highlights that genetically at\u2010risk\n                      <jats:italic>C9orf72<\/jats:italic>\n                      patients exhibit altered body composition. These findings align with the growing recognition that changes in genetic frontotemporal dementia\/amyotrophic lateral sclerosis (FTD\/ALS) extend beyond cognitive\/motor symptoms and include early alterations in broader physiological function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71669","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:21:08Z","timestamp":1784110868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in body composition in genetic\n                    <i>C9orf72<\/i>\n                    carriers: The role of the hypothalamus and thalamus"],"prefix":"10.1002","volume":"22","author":[{"given":"Rebekah M.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Brain and Mind Centre The University of Sydney  Sydney Australia"},{"name":"Department of Neurology Royal Prince Alfred Hospital  Sydney 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