{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:51Z","timestamp":1785297951666,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Up to 90% of Down syndrome (DS) patients develop Alzheimer's disease (AD). Sleep disturbance, affecting over 75% of DS patients, is implicated in AD pathogenesis. The thalamus, central to sleep and arousal, shows early vulnerability in DS\u2010related AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Structural 3T MRI scans from 253 DS participants (119 males, mean age 43.0\u00a0\u00b1\u00a09.4 years) and 36 controls (30 males, mean age 43.1\u00a0\u00b1\u00a012.2 years) from the Alzheimer's Biomarker Consortium\u2010Down Syndrome (ABC\u2010DS) study were analyzed, alongside neurodegenerative plasma biomarker assays (phosphorylated tau [pTau]181, pTau217, neurofilament light chain [NfL], amyloid beta [A\u03b2]40, A\u03b242).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In DS, intracranial volume\u2010adjusted thalamic volume declined with age (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a0\u22122.589,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.00987), approximating 2.5% loss per decade. This was linear, gray matter involution\u2010independent, and heterogeneous across nuclei, correlating negatively with pTau and NfL. Controls exhibited no significant volumetric changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Anteromedial and posterior thalamic shrinkage in DS AD mirrors sporadic AD. Associations with neurodegenerative biomarkers support thalamic atrophy as a sensitive marker of DS\u2010related AD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71671","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:21:26Z","timestamp":1784085686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural MRI across lifespan reveals differential thalamic trajectories in Down syndrome"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-7169","authenticated-orcid":false,"given":"Muhammad","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge Cambridgeshire UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust Fulbourn Hospital  Cambridge Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Zaman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge Cambridgeshire UK"},{"name":"Cambridgeshire and Peterborough NHS Foundation Trust Fulbourn Hospital  Cambridge Cambridgeshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Alzheimer's Biomarker Consortium on Down Syndrome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cambridge  Cambridge Cambridgeshire 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