{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:55:34Z","timestamp":1790052934448,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy (LATE), and Alzheimer's disease (AD) are associated with TAR DNA\u2010binding protein 43 (TDP\u201043) pathology. A positron emission tomography (PET) tracer targeting TDP\u201043 aggregates could improve early diagnosis and guide treatment development for TDP\u201043\u2013related conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Specific binding was evaluated using fluorescent labeling of compound, surface plasmon resonance (SPR), and autoradiography (ARG). Brain PET imaging in rats, nonhuman primate (NHP), and a disease mouse model was performed to characterize tracer pharmacokinetics and in vivo target binding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      JNJ\u2010TDP43\u20101 exhibited high binding affinity for pathological TDP\u201043 (K\n                      <jats:sub>d<\/jats:sub>\n                      \u00a0=\u00a07.1\u00a0nM) and remarkable selectivity over other proteinopathies. PET imaging demonstrated robust brain uptake and rapid washout in rodents and NHP. In vivo target engagement was confirmed in an AAV\u2010hTDP43 disease model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]JNJ\u2010TDP43\u20101 is a promising PET ligand for early diagnosis and evaluating therapies in TDP\u201043\u2010related diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71675","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T04:46:02Z","timestamp":1784436362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development and characterization of a novel TDP\u201043 positron emission tomography tracer: [\n                    <sup>18<\/sup>\n                    F]JNJ\u2010TDP43\u20101"],"prefix":"10.1002","volume":"22","author":[{"given":"Chunfang A.","family":"Xia","sequence":"first","affiliation":[{"name":"Discovery Technologies and Molecular Pharmacology Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani","family":"Salarian","sequence":"additional","affiliation":[{"name":"Discovery Technologies and Molecular Pharmacology Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Gartshore","sequence":"additional","affiliation":[{"name":"Discovery Technologies and Molecular Pharmacology Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Scaglione","sequence":"additional","affiliation":[{"name":"Neuroscience Biomarkers Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hayes","sequence":"additional","affiliation":[{"name":"Global Discovery Chemistry Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglong","family":"Liu","sequence":"additional","affiliation":[{"name":"Global Discovery Chemistry Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Ming","family":"Tsai","sequence":"additional","affiliation":[{"name":"Discovery Technologies and Molecular Pharmacology Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Echavarren","sequence":"additional","affiliation":[{"name":"Global Discovery Chemistry Johnson &amp; Johnson  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Cid","sequence":"additional","affiliation":[{"name":"Global Discovery Chemistry Johnson &amp; Johnson  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Matzeu","sequence":"additional","affiliation":[{"name":"Preclinical Sciences and Translational Safety Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Katrin","family":"Szardenings","sequence":"additional","affiliation":[{"name":"Discovery Technologies and Molecular Pharmacology Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.07.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2024.11.012"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003802"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00025"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx063"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13588"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlae032"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010021\u201000503\u2010x"},{"key":"e_1_2_11_11_1","first-page":"147","article-title":"TDP\u201043 in aging and Alzheimer's disease\u2014a review","volume":"4","author":"Wilson AC","year":"2011","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094705"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010020\u201000513\u20107"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010024\u201000419\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.838034"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042305\u20103"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307\u2010022\u201001779\u20101"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009722"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064540\u20106"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20103327\u20104_15"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010020\u201001952\u20109"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44303\u2010026\u201000138\u2010x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102020\u2010002197"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01759"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14516"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:37:43Z","timestamp":1785296263000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/alz.71675"],"URL":"https:\/\/doi.org\/10.1002\/alz.71675","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71675"}}