{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:04Z","timestamp":1788671524262,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Modifiers of the association between hormone replacement therapy (HRT) use and dementia risk and responsive subgroups, are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In 183,450 postmenopausal women from the UK Biobank (mean 13.3 years follow\u2010up), multivariable Cox regression models evaluated associations between HRT use (\u22651 year) and all\u2010cause dementia and dementia subtypes. Stratified analyzes assessed modification by menopause type, lifetime estrogen exposure, apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      )\n                      <jats:italic>\u025b4<\/jats:italic>\n                      genotype, and age at HRT initiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Over 2.43 million person\u2010years, 3,948 dementia cases were identified. HRT use was associated with lower all\u2010cause dementia (hazard ratio [HR] 0.90; 95% CI, 0.84\u20130.96), with stronger associations in surgical menopause (0.74, 0.65\u20130.84),\n                      <jats:italic>APOE \u025b4<\/jats:italic>\n                      carriers (0.87, 0.80\u20130.95) and women with lower endogenous estrogen exposure (0.84, 0.77\u20130.93). Initiation between ages 46 and 56 conferred the greatest benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>HRT use was associated with lower dementia risk, and these findings may help inform more tailored approaches to HRT prescribing in relation to women's lifetime dementia risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71679","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:01:51Z","timestamp":1787742111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hormone replacement therapy and dementia risk among postmenopausal women: Identifying responsive subgroups in the UK Biobank"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3681-1342","authenticated-orcid":false,"given":"Steven","family":"Squires","sequence":"first","affiliation":[{"name":"University of Exeter Medical School  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha NM","family":"Saleh","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3332-8454","authenticated-orcid":false,"given":"Luke C","family":"Pilling","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L","family":"Atkins","sequence":"additional","affiliation":[{"name":"University of Exeter Medical School  Exeter 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