{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:30:48Z","timestamp":1791862248545,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U24AG057437"],"award-info":[{"award-number":["U24AG057437"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG054029"],"award-info":[{"award-number":["R01AG054029"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG061848"],"award-info":[{"award-number":["R01AG061848"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG079142"],"award-info":[{"award-number":["R01AG079142"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Blood plasma biomarkers identifying Alzheimer's disease (AD) neuropathology offer accessible and scalable alternatives to lumbar puncture and positron emission tomography (PET) scans, with potential efficiency gains in clinical trial recruitment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We evaluated the impact of a blood\u2010based screening algorithm on recruitment for the AHEAD 3\u201045 trial testing lecanemab in preclinical AD. The algorithm was developed during initial screening without blood plasma and subsequently deployed using a Mixture of Experts prediction model to estimate amyloid PET positivity; analyses reflect prospective enrichment and model characterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The algorithm incorporating amyloid beta A  A  and subsequently adding percent phosphorylated tau 217 (%p\u2010tau217), reduced ineligibility on amyloid PET from 71% to 31%. Latent class analysis identified low, intermediate, and high amyloid groups. Model\u2010based analyses indicated %p\u2010tau217 predicts High amyloid group, whereas A  A  was more specific for the low group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Blood plasma screening reduced participant and site burden, while preserving enrichment for amyloid positivity for a preclinical AD trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71681","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:00:26Z","timestamp":1788951626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["More efficient screening for preclinical Alzheimer's clinical trials using mixture of experts"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8951-1326","authenticated-orcid":false,"given":"Oliver","family":"Langford","sequence":"first","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rema","family":"Raman","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Aisen","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa","family":"Sperling","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Johnson","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Molina\u2010Henry","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Sachdev","sequence":"additional","affiliation":[{"name":"Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Li","sequence":"additional","affiliation":[{"name":"Eisai Inc.  Nutley New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Jimenez\u2010Maggiora","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B","family":"Braunstein","sequence":"additional","affiliation":[{"name":"C2N Diagnostics  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Birkenbihl","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Cuppels","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel F.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Harvard Medical School Brigham and Women's Hospital Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Rissman","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Donohue","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute, Keck School of Medicine University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.044511"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12748"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000202956"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.0387"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13686"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042596\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000874\u20109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010201092"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11634\u2010019\u201000373\u20108"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.803"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13542"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lindif.2024.102463"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00227\u2010021\u201003972\u20102"},{"key":"e_1_2_10_18_1","unstructured":"MurphyK MurphyTB MoEClust: Gaussian Parsimonious Clustering Models with Covariates and a Noise Component.2023.https:\/\/cran.r\u2010project.org\/package=MoEClust"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-84858-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.11.007"},{"key":"e_1_2_10_21_1","unstructured":"MayerM WatsonD Kernelshap: Kernel SHAP.2024.https:\/\/CRAN.R\u2010project.org\/package=kernelshap"},{"key":"e_1_2_10_22_1","unstructured":"CovertI LeeSI Improving kernelshap: practical shapley value estimation using linear regression. 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