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Delayed memory was tested after 4 h and compared to immediate memory. LC contrast was measured via LC\u2010sensitive MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Memory was lower, independent of delay or emotional valence, and LC contrast was more strongly reduced in those with MCI compared to OAs. In OAs, LC contrast correlated with delayed memory and was mildly associated with LC activity during successful encoding. All groups remembered emotional images better than neutral ones, though memory was greatly impaired in those with MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>LC contrast was associated with lower brain activity during encoding and emotional salience processing. Its relationship to delayed memory was evident in those with MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71682","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:34:13Z","timestamp":1785929653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BOLD fMRI activations and LC contrast associated with successful episodic memory in healthy older adults and MCI"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-5537","authenticated-orcid":false,"given":"Lucia","family":"Penalba\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University Magdeburg Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeo\u2010Jin","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University Magdeburg Magdeburg Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE) Otto\u2010von\u2010Guericke University Magdeburg  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Aziz Sancar Institute of Experimental Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia Daniela","family":"Femminella","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Loane","sequence":"additional","affiliation":[{"name":"Institute of Cognitive Neuroscience University College London (UCL) United Kingdom.  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