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Postmortem association of [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 binding with pathology of AD and non\u2010AD tauopathies is undefined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 binding, [\n                      <jats:sup>3<\/jats:sup>\n                      H]Pittsburgh compound B ([\n                      <jats:sup>3<\/jats:sup>\n                      H]PiB) binding, and MAO\u2010B activity assays in brain homogenates, with [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 autoradiography and MAO\u2010B immunoreactivity in relation to glial fibrillary acidic protein (GFAP), major histocompatibility complex II (MHC\u2010II), A\u03b2, phosphorylated tau, cyano\u2010Pittsburgh compound B (cyano\u2010PiB), and X\u201034 on brain sections from AD, non\u2010AD tauopathies, and nondemented controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 binding correlated with MAO\u2010B activity and [\n                      <jats:sup>3<\/jats:sup>\n                      H]PiB binding, with highest levels in AD. [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 autoradiography corresponded to MAO\u2010B\/GFAP\u2010immunoreactive astrocytes associated with A\u03b2 deposits in plaques and vasculature, more closely than to tau pathology. [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 binding and MAO\u2010B activity in non\u2010AD tauopathies partially overlapped controls and AD, with MAO\u2010B\/GFAP\u2010immunoreactive astrocytes in areas with tau pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]SMBT\u20101 is a promising biomarker of MAO\u2010B reactive astrocytes in AD and non\u2010AD tauopathies.\n                    <\/jats:p>\n                  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