{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:09Z","timestamp":1788671529182,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG070841"],"award-info":[{"award-number":["R01 AG070841"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F32AG084196\u201001"],"award-info":[{"award-number":["F32AG084196\u201001"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5\u2010HT) and sex, has not been directly tested.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We isolate tau pathology to whole DRN (DRN\n                      <jats:sup>Tau<\/jats:sup>\n                      ), serotonin neurons of the DRN (5\u2010HT\n                      <jats:sup>Tau<\/jats:sup>\n                      ), or non\u2010serotonergic neurons of the DRN (non5HT\n                      <jats:sup>Tau<\/jats:sup>\n                      ). We use longitudinal EEG recordings, in male and female mice, to determine the contributions of DRN neuronal subtypes to sleep disruption within the context of prodromal AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      DRN\n                      <jats:sup>Tau<\/jats:sup>\n                      , 5\u2010HT\n                      <jats:sup>Tau<\/jats:sup>\n                      , and non5HT\n                      <jats:sup>Tau<\/jats:sup>\n                      disrupt sleep architecture. 5\u2010HT\n                      <jats:sup>Tau<\/jats:sup>\n                      and non5HT\n                      <jats:sup>Tau<\/jats:sup>\n                      further disrupt sleep\u2010wake orchestration and exhibit sex\u2010dependent alterations that coincide with changes in delta wave power.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Tau\u2010mediated sleep dysfunction may be driven by various cellular subtypes of the DRN, are primarily sexually divergent, and may resultant in changes in 5\u2010HT activity and relative spectral brain wave contributions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71687","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:54:14Z","timestamp":1786092854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dorsal raphe tau pathology disrupts sleep\u2010wake orchestration and sleep architecture in a sex\u2010specific manner"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0597-0199","authenticated-orcid":false,"given":"Louis 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Pharmacology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley O.","family":"McCoy","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa  Iowa City Iowa 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