{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:34:27Z","timestamp":1793208867758,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["24CBIDR\u20101185483 AARG\u201020\u2010678884 AARGD\u201022\u2010972378"],"award-info":[{"award-number":["24CBIDR\u20101185483 AARG\u201020\u2010678884 AARGD\u201022\u2010972378"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/14339\u20103 2024\/03917\u20107"],"award-info":[{"award-number":["2020\/14339\u20103 2024\/03917\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp;amp; Dementia"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Sex differences in dementia\u2010related neuropathology are understudied in diverse populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed sex differences in neuropathological and cognitive data from the Brazilian Biobank for Aging Studies. Cognitive performance was evaluated with the Clinical Dementia Rating\u2013Sum of Boxes (CDR\u2010SOB). Linear and logistic regression models were conducted, including interaction terms for age, race, and education.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In 2229 participants (50.7% female, mean age \u00b1 SD 75.4\u00a0\u00b1\u00a012.3 years, 62.1% White), female sex was associated with a higher odds of AD pathology (Braak: odds ratio [OR]\u00a0=\u00a01.42, 95% confidence interval [CI] \u00a0=\u00a01.17\u20131.72; Consortium to Establish a Registry for Alzheimer's Disease (CERAD): OR\u00a0=\u00a01.58, 95% CI\u00a0=\u00a01.27\u20131.98), and trans\u2010activation response (TAR) DNA\u2010binding protein 43 (TDP\u201043) (OR\u00a0=\u00a01.77, IC 95%\u00a0=\u00a01.22\u20132.59), and lower odds of Lewy body disease (OR\u00a0=\u00a00.69, 95% CI\u00a0=\u00a00.51\u20130.95). Female participant had worse cognitive performance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a01.56, 95% CI\u00a0=\u00a01.03\u20132.10). Sex modified associations of Braak, CERAD, TDP\u201043, and cerebral amyloid angiopathy with cognition. Age also interacted with sex and pathology on CDR\u2010SOB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Sex differences in the associations between sex and neuropathology suggest the need for sex\u2010informed dementia research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71691","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:01:56Z","timestamp":1785121316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in dementia pathology and cognitive performance in a population\u2010based, ethnically diverse Brazilian autopsy study"],"prefix":"10.1002","volume":"22","author":[{"given":"Karen Luiza Ramos","family":"Socher","sequence":"first","affiliation":[{"name":"Cognitive and Behavioral Neurology Unit, Department of Neurology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi Vidal","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Physiopathology in Laboratory (LIM\u201022) Department of Pathology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Ribeiro","family":"Paes","sequence":"additional","affiliation":[{"name":"Physiopathology in Laboratory (LIM\u201022) Department of Pathology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Fernando Oliveira","family":"Justo","sequence":"additional","affiliation":[{"name":"Physiopathology in Laboratory (LIM\u201022) Department of Pathology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo 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Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Reis","family":"Ururahy","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Oto Cunha","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Physiopathology in Laboratory (LIM\u201022) Department of Pathology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines Liguori","family":"Padr\u00e3o","sequence":"additional","affiliation":[{"name":"Physiopathology in Laboratory (LIM\u201022) Department of Pathology Faculdade de Medicina, Universidade de S\u00e3o Paulo  S\u00e3o Paulo 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