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The scientists, methodologists, subject\u2010matter experts, and clinicians on this perspective strongly recommend that the Cochrane editorial board consider a call for editorial response, correction of press materials, or commissioned reply to this review for four overarching reasons: (1) decision to pool antibodies that do and do not clear beta amyloid, (2) decision to include studies from a time when biomarkers of Alzheimer's disease were not available, (3) analytical and methodological limitations of the approach used, (4) conflating the distinct roles and methodological processes of systematic review and guideline methodologies, (5) contextualizing the present critique within the existing evidence\u2010synthesis literature, and (6) mechanistic inference beyond the scope of the presented analyses. Conclusions that may not accurately reflect treatment\u2010specific effects could cause significant downstream clinical and psychosocial harm to those currently undergoing treatment and their family members as well as individuals considering participation in Alzheimer's clinical trials.<\/jats:p>","DOI":"10.1002\/alz.71696","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:12:43Z","timestamp":1785222763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recent Cochrane review has serious flaws: A perspective of clinicians and researchers from around the world"],"prefix":"10.1002","volume":"22","author":[{"given":"Heather M.","family":"Snyder","sequence":"first","affiliation":[{"name":"Division of Medical and Scientific Relations and Medical Affairs Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malavika P.","family":"Tampi","sequence":"additional","affiliation":[{"name":"Division of Medical and Scientific Relations and Medical Affairs Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Aisen","sequence":"additional","affiliation":[{"name":"Epstein Family Alzheimer's Therapeutic Research Institute University of Southern California  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Allegri","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Instituto Neurol\u00f3gico Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana G.","family":"Apostolova","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Atri","sequence":"additional","affiliation":[{"name":"Banner Health  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena","family":"Aurora","sequence":"additional","affiliation":[{"name":"Division of Medical and Scientific Relations and Medical Affairs Alzheimer's Association  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Behavioral and Cognitive Neurology Unit, Faculdade de Medicina Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Crivelli","sequence":"additional","affiliation":[{"name":"Fleni\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Brain Health University of Nevada  Las Vegas Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"de Strooper","sequence":"additional","affiliation":[{"name":"UK Dementia research institute at University College London KULeuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick C.","family":"Fox","sequence":"additional","affiliation":[{"name":"Dementia Research Centre UCL Institute of Neurology, Greater London  London UK"},{"name":"Ann Romney Center for Neurologic Diseases and the Department of Neurology Brigham and Women's Hospital Harvard Medical School  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Tenenholz","family":"Grinberg","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Pathology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[{"name":"Queen Square Institute of Neurology University College London, Greater London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Levey","sequence":"additional","affiliation":[{"name":"Goizueta Brain Health Institute Emory School of Medicine  Brookhaven Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lopez","sequence":"additional","affiliation":[{"name":"Departments of Neurology Psychiatry and Clinical &amp; 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