{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:56:25Z","timestamp":1792652185063,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>We evaluated lecanemab's safety and cognitive outcomes in Chinese patients with Alzheimer's disease (AD) and the utility of blood\u2010based biomarkers (BBMs) for treatment guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A multicenter, real\u2010world cohort enrolled 1042 patients receiving lecanemab, with 453, 359, 97 patients followed up at 3, 6, 12 months, respectively. Safety outcomes included amyloid\u2010related imaging abnormalities (ARIA) and infusion\u2010related reactions (IRRs), and the main\n                      <jats:italic>clinical<\/jats:italic>\n                      outcome was Clinical Dementia Rating Scale\u2013Sum of Boxes (CDR\u2010SB) score change.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 1,042 patients, ARIA occurred in 7.87%, and IRRs in 16.12%. Discontinuation was 16.51%, mainly due to financial burden. CDR\u2010SB did not change at 12 months overall or in any subgroup. High\u2010accuracy BBMs were the sole AD biomarker assay in 5.28%, with comparable outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      Lecanemab exhibited\n                      <jats:italic>favorable<\/jats:italic>\n                      12\u2010month safety, with no clear evidence of cognitive decline, and BBMs hold potential for treatment guidance. Further studies using a control group are now warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71702","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:36:02Z","timestamp":1786001762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lecanemab use in Chinese patients with Alzheimer's disease: a 12\u2010month multicenter real\u2010world study"],"prefix":"10.1002","volume":"22","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Huanhu Hospital Affiliated to Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huidong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Medical Center on Aging Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Neuroscience Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China The Second Affiliated Hospital, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Zhengzhou University People's Hospital Henan University People's Hospital Henan Provincial People's Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Huanhu Hospital Affiliated to Tianjin Medical University  Tianjin 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