{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:53Z","timestamp":1788671573564,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma phosphorylated tau 217 (p\u2010tau217) is a promising biomarker for monitoring treatment response in Alzheimer's disease (AD), but its longitudinal dynamics and clinical relevance remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this prospective real\u2010world study, 153 patients with early AD receiving lecanemab were analyzed. Longitudinal changes in plasma p\u2010tau217 were assessed, and trajectory patterns were identified using clustering and slope\u2010based approaches. Associations with baseline factors and cognitive outcomes were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 levels decreased significantly from 3 months, with the greatest decline between 3 and 6 months, followed by a plateau. Two distinct trajectory groups were identified. Patients in the greater reduction group showed more favorable cognitive trajectories, particularly slower progression in Clinical Dementia Rating\u2013Sum of Boxes (CDR\u2010SB) scores. Hypertension was associated with a diminished biomarker response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings support plasma p\u2010tau217 as an early pharmacodynamic biomarker and highlight its potential role in guiding individualized treatment strategies in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71705","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:53:56Z","timestamp":1785488036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneity in plasma p\u2010tau217 response and its association with cognitive trajectories under lecanemab treatment"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-0302","authenticated-orcid":false,"given":"Sung Hoon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Seong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea University Guro Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Na","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Radiology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inseon","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Radiology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyundoo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Bredis Healthcare Inc.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangho","family":"Choi","sequence":"additional","affiliation":[{"name":"Bredis Healthcare Inc.  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Seon","family":"Eo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Korea University Guro Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Il","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Radiology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungmi","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Beom","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurology Korea University Guro Hospital, Korea University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002505\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12134"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3392"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.71231"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2024.23.4.165"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2019.18.3.77"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2023.22.1.1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2024.23.3.117"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.5319"},{"key":"e_1_2_10_15_1","unstructured":"Administration USFaD.Prescribing information for Leqembi Available at: Accessed April 8 2025.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/761269s008lbl.pdf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.120618"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000011833"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114022"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201000835\u2010z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068732\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100234\u2010x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(18)30318\u20101"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1536001"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26460"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14233"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13453"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.64898\/2026.01.25.26344738"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001763\u20101"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001886\u20105"}],"container-title":["Alzheimer's &amp; 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