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Therefore, iRBD provides a suitable window for early intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In the monocentric randomized controlled trial \u201c\n                      <jats:bold>Cog<\/jats:bold>\n                      nitive\n                      <jats:bold>Tr<\/jats:bold>\n                      aining &amp; a Healthy,\n                      <jats:bold>A<\/jats:bold>\n                      ct\n                      <jats:bold>i<\/jats:bold>\n                      ve\n                      <jats:bold>L<\/jats:bold>\n                      ifestyle Program for People with Isolated\n                      <jats:bold>R<\/jats:bold>\n                      EM Sleep\n                      <jats:bold>B<\/jats:bold>\n                      ehaviour\n                      <jats:bold>D<\/jats:bold>\n                      isorder\u201d (CogTrAiL\u2010RBD), the feasibility and behavioral effects of a 5\u2010week digital, adaptive, multidomain cognitive training alongside a module promoting a healthy lifestyle (INT) were compared to a waiting\u2010list control group (CON) in 82 individuals with polysomnography\u2010confirmed iRBD. The primary outcome was change in executive functions at 6 weeks post\u2010allocation (t1) and at 6\u2010month follow\u2010up (t2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      For executive functions, we found positive intervention effects for the INT versus CON with a medium effect at t1 (\n                      <jats:italic>d\u00a0<\/jats:italic>\n                      =\u00a00.500, 95% confidence interval [CI]: 0.221\u20130.779) and a small effect at t2 (\n                      <jats:italic>d\u00a0<\/jats:italic>\n                      =\u00a00.397, 95% CI: 0.115\u20130.679).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CogTrAiL\u2010RBD provides initial evidence for the feasibility and potential cognitive benefits of cognitive training within a lifestyle\u2010guidance framework in individuals with iRBD. Its suitability for dementia prevention warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71707","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:57:25Z","timestamp":1785941845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL\u2010RBD"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-7762","authenticated-orcid":false,"given":"Anja","family":"Ophey","sequence":"first","affiliation":[{"name":"Department of Medical Psychology | Neuropsychology and Gender Studies, Center for Neuropsychological Diagnostics and Intervention (CeNDI), Faculty of Medicine and University Hospital Cologne University of Cologne  Cologne Germany"},{"name":"Cognitive Neuroscience 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