{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:52Z","timestamp":1788671572139,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","award":["77225"],"award-info":[{"award-number":["77225"]}],"id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Polypharmacy, potentially inappropriate medications (PIMs), and drugs associated with drug\u2010induced cognitive impairment (DICI) are highly prevalent in older adults and may affect cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This observational retrospective study included 2379 patients evaluated at Ace Alzheimer Center Barcelona. Medication data were extracted from electronic health records using a large language model (LLM). Polypharmacy (\u22655), hyperpolypharmacy (\u226510), PIMs, and DICI drugs were analyzed across cognitive stages, Alzheimer's disease biomarkers, ApoE subtype, and estimated glomerular filtration rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among patients with cognitive impairment (Clinical Dementia Rating [CDR] \u2265 0.5), 67% presented polypharmacy and 21% hyperpolypharmacy. Higher odds of polypharmacy were observed across the CDR scale, while higher education showed a protective effect. Altered renal function was found in 20.8% of patients with polypharmacy. Indeed, significant differences were found between amyloid beta\u2010positive and negative (A\u03b2\n                      <jats:sup>+<\/jats:sup>\n                      \/A\u03b2\n                      <jats:sup>\u2212<\/jats:sup>\n                      ) subjects and between the whole population and subjects participating in clinical trials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Polypharmacy is extremely common in patients attending memory clinics. LLMs could facilitate systematic structured medication reviews.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71708","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:01:29Z","timestamp":1787655689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When treatment becomes risk: polypharmacy and inappropriate prescribing in cognitive impairment in 2379 consecutive patients from a memory clinic"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-2864","authenticated-orcid":false,"given":"Xavier","family":"Morat\u00f3","sequence":"first","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases (CIBERNED) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Hinojosa\u2010Calleja","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Jofresa","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Calm","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya  Barcelona Spain"},{"name":"Networking Research Center on Neurodegenerative Diseases 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