{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:54Z","timestamp":1788671574577,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cerebral amyloid angiopathy (CAA) frequently co\u2010occurs with Alzheimer's disease (AD), generating mixed vascular\u2013neurodegenerative phenotypes. Plasma phosphorylated tau (p\u2010tau)217 is a robust biomarker of AD, but its performance in CAA remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We studied 231 participants, including 50 patients with CAA (Boston v2.0), 154 with AD, and 27 cognitively unimpaired controls. Plasma p\u2010tau217 was measured on an automated platform and compared to cerebrospinal fluid (CSF)\u2013defined AD status. Associations with magnetic resonance imaging (MRI) markers of CAA burden were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among CAA participants, 29 met CSF criteria for AD co\u2010pathology. Plasma p\u2010tau217 discriminated CAA patients with and without AD co\u2010pathology (area under the curve\u00a0=\u00a00.920) and showed no association with MRI markers of CAA burden. Predefined cut\u2010offs (\u2265 0.27 pg\/mL and \u2265 0.34 pg\/mL) yielded high accuracy for identifying AD co\u2010pathology within CAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Plasma p\u2010tau217 shows high diagnostic accuracy for identifying AD co\u2010pathology in CAA and is not associated with MRI markers of CAA burden, supporting its specificity for AD\u2010related pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71709","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:47:01Z","timestamp":1785908821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma p\u2010tau217 detects Alzheimer's disease co\u2010pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2097-4430","authenticated-orcid":false,"given":"Aida","family":"Fern\u00e1ndez\u2010Lebrero","sequence":"first","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Servei de Neurologia Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Life Sciences Universitat Pompeu Fabra  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Jim\u00e9nez\u2010Balado","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Garc\u00eda\u2010Escobar","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Servei de Neurologia Hospital del Mar  Barcelona 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Mar\u00eda","family":"Manero\u2010Borr\u00e0s","sequence":"additional","affiliation":[{"name":"Servei de Neurologia Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Ludovica","family":"Gramegna","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Viles","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rodr\u00edguez","family":"Campello","sequence":"additional","affiliation":[{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Servei de Neurologia Hospital del Mar  Barcelona Spain"},{"name":"Department of Medicine and Life Sciences Universitat Pompeu Fabra  Barcelona 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