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The PRS remained predictive among AAs after apolipoprotein E (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 adjustment (HR\u00a0=\u00a01.53, 95% CI: 1.03\u20132.27). Higher PRS associated with lower baseline cognition and faster decline (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>\n                      PRS conferred greater ADRD risk in AAs and comparable rates of cognitive decline, despite stronger discrimination in EUs, adding to the limited knowledge of genetic contributions to ADRD risk among AAs beyond\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 alleles.\n                    <\/jats:p>\n                  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