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We estimate resistance as lower\u2010than\u2010expected NEO tau levels in training\u2010independent individuals (N\n                      <jats:sub>Test<\/jats:sub>\n                      \u00a0=\u00a0579) to assess sex\u2010specific resistance associates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Relative feature importance in sex\u2010specific expectation models differed in 97.7% of variables (false discovery rate\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      value &lt;\u00a00.001). Age and A\u03b2 burden associated with male resistance, while Clinical Dementia Rating, latent Preclinical Alzheimer's Cognitive Composite, and adjusted hippocampal volume were associates in both sexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our study highlights sex\u2010specific biological and clinical factors in the prediction of NEO tau and associates of resistance. Understanding sex\u2010specific resistance pathways informs targeted Alzheimer's interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71716","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:59:34Z","timestamp":1786003174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex specificity of resistance to caTAUstrophe"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3506-9708","authenticated-orcid":false,"given":"Maria","family":"Carrigan","sequence":"first","affiliation":[{"name":"Alzheimer Center Neurology Vrije Universiteit  Amsterdam The Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam The Netherlands"},{"name":"Faculty of Science Swammerdam Institute for Life Sciences University of Amsterdam  Amsterdam The Netherlands"},{"name":"Massachusetts General Hospital Harvard Medical School  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