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We compared three group\u2010level and seven individualized tau PET quantification approaches (and a voxel\u2010wise spatial extent metric) by (1) percentage change, (2) sensitivity to change, and (3) clinical associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Percentage change was highest in a composite temporal ROI (temporal\u2010meta) in CU and CI. Individualized Braak stage\u2013based (CU) and connectivity\u2010informed (CU\/CI) approaches, and tau spatial extent (CI), performed well for sensitivity to change and clinical associations, but temporal\u2010meta was consistently a top performer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Contrary to our hypothesis, temporal\u2010meta quantification was most robustly associated with biological and clinical progression across disease stages, making it well suited for monitoring AD progression with tau PET.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71718","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:10:13Z","timestamp":1787206213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Group\u2010level versus individualized approaches for capturing tau PET changes and clinical progression in Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-1120","authenticated-orcid":false,"given":"Hannah","family":"de Bruin","sequence":"first","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam the Netherlands"},{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Groot","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam, Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience Neurodegeneration  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), University Hospital Ludwig Maximilian University of Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsmarieke","family":"van de Giessen","sequence":"additional","affiliation":[{"name":"Radiology &amp; Nuclear Medicine Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc  Amsterdam the Netherlands"},{"name":"Amsterdam Neuroscience Brain Imaging  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Shcherbinin","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kotari","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana O.","family":"Svaldi","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande A. 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