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Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>CU older adults underwent clinical evaluation and cerebrospinal fluid (CSF) assessment of fibrinogen, A\u03b242, total tau (tTau), phosphorylated tau 181 (pTau181), and YKL\u201040. Linear regression tested baseline associations. Linear mixed\u2010effects models tested whether baseline fibrinogen predicted longitudinal pTau181 change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 169 CU participants with baseline fibrinogen, 87 had longitudinal pTau181 measurements (mean follow\u2010up 2.5\u2010years). Higher fibrinogen was associated with elevated YKL\u201040 (\u03b2\u00a0=\u00a00.28, 95% confidence interval [CI] [0.11, 0.45]) but not A\u03b242, tTau, or pTau181 at baseline. Baseline fibrinogen modified longitudinal pTau181 trajectories (interaction \u03b2\u00a0=\u00a00.11, 95% CI [0.04, 0.19]), with only participants above the median showing significant pTau181 increases (\u03b2\u00a0=\u00a00.13, 95% CI [0.08, 0.18]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CSF fibrinogen associates cross\u2010sectionally with glial inflammation and predicts accelerated tau accumulation in preclinical AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71720","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T10:10:35Z","timestamp":1786529435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-5993","authenticated-orcid":false,"given":"Christos Panagiotis","family":"Lisgaras","sequence":"first","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"The Nathan S. Kline Institute for Psychiatric Research New York State Office of Mental Health  Orangeburg New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tovia","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Figueredo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pirraglia","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb H","family":"Radtke","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Pathology, Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah N","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Pathology, Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Karvelas","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Pathology, Molecular and Cell\u2010Based Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bernal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute at UCL  London UK"},{"name":"Center for Brain Research Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Glodzik","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Institute, Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony J","family":"de Leon","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Institute, Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Beth","family":"McIntire","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Institute, Department of Radiology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allal","family":"Boutajangout","sequence":"additional","affiliation":[{"name":"Center for Cognitive Neurology, Department of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Alzheimer's Disease Research Center NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"},{"name":"Center for Cognitive Neurology, Department of Neurology NYU Grossman School of Medicine  New York New York USA"},{"name":"Alzheimer's Disease Research Center NYU Grossman School of Medicine  New York New York USA"},{"name":"Neuroscience Institute NYU Grossman School of Medicine  New York New York USA"},{"name":"Department of Pathology NYU Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Ramos\u2010Cejudo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, IR SANT PAU Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, IR SANT PAU Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Sant Pau Memory Unit, Department of Neurology, IR SANT PAU Hospital de la Santa Creu i Sant Pau  Barcelona Spain"},{"name":"Barcelona Down Medical Center Fundaci\u00f3 Catalana de S\u00edndrome de Down  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Akassoglou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Weill Institute for Neurosciences University of California  San Francisco California 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