{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:13Z","timestamp":1788671533771,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012479","name":"Weston Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Staging amyloid beta (A\u03b2) burden along a continuous spectrum provides clinically relevant information. Conventional phosphorylated tau (p\u2010tau)217 reliably identifies amyloid positron emission tomography (PET) positivity, but its ability to capture the full A\u03b2 continuum is limited. Recently developed brain\u2010derived (BD) p\u2010tau217 assays enrich for central nervous system tau species and may improve specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We tested how closely BD p\u2010tau217 reflected continuous A\u03b2 and how accurately it could classify participants as A\u03b2 positive or negative across different Centiloid (CL) thresholds in 924 participants from the Alzheimer's Disease Neuroimaging Initiative. Conventional and BD cerebrospinal fluid (CSF) and plasma p\u2010tau217 biomarkers were quantified using the Alamar NULISAseq panel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Across the full cohort, plasma BD p\u2010tau217 demonstrated the strongest continuous association with PET CL (\n                      <jats:italic>\n                        R\n                        <jats:sup>2<\/jats:sup>\n                        \u00a0=\n                      <\/jats:italic>\n                      \u00a00.63), and the best prediction across the CL spectrum (root mean square error =\u00a0=\u00a024.5). Prediction was precise in cognitively unimpaired participants at low CL and reasonably accurate in cognitively impaired participants across intermediate\u2010to\u2010high CL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Plasma BD p\u2010tau217 best captured the amyloid PET continuum, with BD processing improving discrimination in plasma but not CSF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71723","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:57:52Z","timestamp":1786003072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting continuous amyloid PET levels with CSF and plasma brain\u2010derived p\u2010tau217"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5593-7717","authenticated-orcid":false,"given":"Lydia","family":"Trudel","sequence":"first","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur C.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Aumont","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Benedet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  M\u00f6ldnal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili\u2010Naz","family":"Hazrati","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Montreal Neurological Institute, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  M\u00f6ldnal Sweden"},{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"},{"name":"UK Dementia Research Institute University College London (UCL)  London UK"},{"name":"Department of Pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vitali","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg  M\u00f6ldnal Sweden"},{"name":"Banner Alzheimer's Institute  Phoenix Arizona USA"},{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rosa\u2010Neto","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Research Institute, Le Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) de l'Ouest\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al; Montreal Neurological Institute  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery, Faculty of Medicine McGill University  Montreal Quebec Canada"},{"name":"Peter O'Donnell Jr. Brain Institute (OBI) University of Texas Southwestern Medical Centre (UTSW)  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae116"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2025.103765"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(25)00350\u20103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12748"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.09.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(25)00227-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70208"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac333"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001302\u2010w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae346"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad042"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14073"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12405"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047286\u20105"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042834\u2010x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536792123"},{"key":"e_1_2_8_18_1","unstructured":"AshtonNJ DenkingerMN.NULISAseq 120\u2010Plex CNS Disease Panel in ADNI Plasma and CSF.2026.https:\/\/ida.loni.usc.edu\/"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14378"},{"key":"e_1_2_8_20_1","unstructured":"LeeJiY KoeppeR HarrisonT JagustW LandauS PET Uniform Resolution Information.2025.https:\/\/ida.loni.usc.edu\/"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000836\u20101"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2026.0054"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5216"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000942\u20102"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010025\u201007270\u20107"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14336"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awag018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182840bbe"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214111"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70624"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200861"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.05.008"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"}],"container-title":["Alzheimer's &amp; 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