{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:12Z","timestamp":1788671532198,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/F\/22\/110052"],"award-info":[{"award-number":["RG\/F\/22\/110052"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Visit\u2010to\u2010visit blood pressure variability (BPV) may be associated with cognitive decline beyond mean blood pressure (BP), but its relevance across treatment contexts remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      We pooled individual\u2010participant data from Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD\u2010MIND) and Systolic Blood Pressure Intervention Trial Memory and Cognition in Decreased Hypertension (SPRINT\u2010MIND) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011,104). Participants had baseline and follow\u2010up cognitive testing and \u22653 BP measurements from 3 months onwards. The primary exposure was systolic BP variation independent of the mean (SBP\u2010VIM). The primary outcome was annualized change in standardized Digit Symbol Substitution or Coding Test Z\u2010scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Each 10% increment in SBP\u2010VIM was independently associated with faster annual cognitive decline (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.008 per year; 95% confidence interval [CI]: \u22120.014 to \u22120.003) after adjustment including mean SBP. Associations were observed in the intensive but not standard BP treatment arms of both trials, although the pooled interaction was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.054).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Higher systolic BPV was associated with accelerated cognitive decline independently of mean BP. The exploratory treatment\u2010context pattern warrants prospective confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71726","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:52:27Z","timestamp":1785498747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Visit\u2010to\u2010visit systolic blood pressure variability, blood pressure treatment intensity, and cognitive decline"],"prefix":"10.1002","volume":"22","author":[{"given":"Yue","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Centre for Neurological Disorders  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Sun","sequence":"additional","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Beijing Institute for Brain Disorders Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S","family":"Markus","sequence":"additional","affiliation":[{"name":"Stroke Research Group, Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology Xuanwu Hospital Capital Medical University, National Centre for Neurological Disorders  Beijing China"},{"name":"Stroke Research Group, Department of Clinical Neurosciences University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.06.045"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21442"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.13656"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4098"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210151"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003422"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010019\u20100425\u2010y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010024\u201006242\u20100"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i6.855"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230\u20108210.176349"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0218492310375723"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062362"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(11)70188\u20100"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04568"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201004986\u20108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035504"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033697"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022206"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac128"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.034"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u20102012\u2010120757"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.70"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4600"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1387"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13664"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010018\u20101108\u2010z"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003133"}],"container-title":["Alzheimer's &amp; 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