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The 90+ Study found women using hormone replacement therapy (HRT) two to three decades before death had lower odds of LATE\u2010NC. We attempted to replicate this finding in a different cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02056) included males (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0640) and females (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01416) aged \u226565 from the Religious Orders Study and Memory and Aging Project with HRT and neuropathology data. We examined the association between HRT and LATE\u2010NC in males and females and between HRT\u2010related and reproductive variables in relation to LATE\u2010NC in females using logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      HRT use within 5 years before or after menopause (odds ratio [OR]\u00a0=\u00a00.70, 95% confidence interval [CI]\u00a0=\u00a00.50 to 0.98,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.03) or for 8 to 16 years (OR\u00a0=\u00a00.44, 95% CI\u00a0=\u00a00.24 to 0.79,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.006) was associated with lower odds of LATE\u2010NC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This finding identifies a potential factor related to LATE risk and highlights the importance of HRT timing and duration for its potential neuroprotective effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71730","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T08:59:11Z","timestamp":1786093151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hormone replacement therapy and its association with LATE\u2010NC in older adults"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5459-1205","authenticated-orcid":false,"given":"Yohana M.","family":"Kim","sequence":"first","affiliation":[{"name":"Joe C. Wen School of Population and Public Health University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Colcord","sequence":"additional","affiliation":[{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Ahmad","family":"Sajjadi","sequence":"additional","affiliation":[{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Andrews","sequence":"additional","affiliation":[{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Rush Alzheimer's Disease Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Kawas","sequence":"additional","affiliation":[{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Corrada","sequence":"additional","affiliation":[{"name":"Joe C. Wen School of Population and Public Health University of California, Irvine  Irvine California USA"},{"name":"School of Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.15.04156"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010022\u201001121\u20105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12662"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010180141"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2023.1324522"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.921504"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117432"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2014"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0025539"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1260427"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105122(99)00005\u20105"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010240899"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.43053"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.17.1934"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.9.688"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.20.2651"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702\u2010025\u201002916\u20100"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25380"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010022\u201002444\u20101"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14202"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlac119"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000374\u20105"},{"key":"e_1_2_8_27_1","unstructured":"Rush Alzheimer's Disease Center.Study Design Summaries.RADC Research Resource Sharing Hub. 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