{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:17Z","timestamp":1788671537067,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG089856"],"award-info":[{"award-number":["R01AG089856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Tooth loss is associated with dementia risk, but mechanisms remain unclear. We examined whether blood\u2010based neurodegenerative biomarkers mediate the edentulism\u2013cognition association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Among 4238 Health and Retirement Study participants aged 50+, we linked edentulism (2012), biomarkers (neurofilament light chain [NfL], glial fibrillary acidic protein [GFAP], phosphorylated tau\u2010181, and amyloid\u2010\u03b2 [A\u03b2] 42\/40; 2016), and 10\u2010year cognitive outcomes (2012\u20132022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Edentulism was associated with higher NfL (\n                      <jats:italic>\u03b2\u00a0=<\/jats:italic>\n                      \u00a04.21) and GFAP (\n                      <jats:italic>\u03b2\u00a0=<\/jats:italic>\n                      \u00a08.06), but not pTau\u2010181 or A\u03b242\/40, and predicted cognitive impairment (hazard ratio [HR] 1.49) and dementia (HR 1.28). GFAP mediated 9.8% and 12.0% of the cognitive impairment and dementia associations, respectively; NfL mediated 9.8% of the dementia association but not cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In this observational cohort, elevated NfL and GFAP were associated with, and accounted for a small proportion of, the edentulism\u2013cognition association. These associative findings support further study of oral health in dementia prevention but do not establish a causal effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71731","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:49:59Z","timestamp":1785941399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Edentulism, blood\u2010based neurodegenerative biomarkers, and 10\u2010year dementia risk: A mediation analysis in a nationally representative United States cohort"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-8609","authenticated-orcid":false,"given":"Xiang","family":"Qi","sequence":"first","affiliation":[{"name":"Rory Meyers College of Nursing New York University  New York New York 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Health East Carolina University Greenville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunrui","family":"Liu","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijing","family":"Xu","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Langa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-244X","authenticated-orcid":false,"given":"Bei","family":"Wu","sequence":"additional","affiliation":[{"name":"NYU Shanghai  Shanghai 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