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We performed association analysis of epigenetic age acceleration with network modules, followed by functional and cell\u2010type enrichment analyses, association analyses of hub proteins with AD endophenotypes, and pseudotime trajectory analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Six network modules were significantly associated with epigenetic age acceleration and were enriched in pathways related to neuronal connectivity, proteostasis, immune activation and remodeling, immune signaling, and immunoepigenetic regulation. Hub proteins demonstrated significant associations with baseline amyloid\/tau\/neurodegeneration biomarkers and longitudinal cognitive changes. Pseudotime analysis revealed continuous, non\u2010linear variation in epigenetic age acceleration along the inferred trajectory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our CSF proteomics study identified neuronal, proteostatic, and immune\u2010related molecular signatures associated with epigenetic age acceleration in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71732","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:03:17Z","timestamp":1785927797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic aging in Alzheimer's disease: Relation to proteome"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7155-3506","authenticated-orcid":false,"given":"Bo\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Epigenome Dynamics Control Research Center (EDCRC) School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunPyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Digital Health, SAIHST Sungkyunkwan University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Department of Digital Health, SAIHST Sungkyunkwan University  Seoul Republic of Korea"},{"name":"Department of Health Sciences and Technology, SAIHST Sungkyunkwan University  Seoul Republic of Korea"},{"name":"Department of Intelligent Precision Healthcare Convergence Sungkyunkwan University  Suwon Republic of 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