{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:12:21Z","timestamp":1788671541133,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K01AG068353"],"award-info":[{"award-number":["K01AG068353"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG079552"],"award-info":[{"award-number":["R21AG079552"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG096669"],"award-info":[{"award-number":["R01AG096669"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F31AG084308"],"award-info":[{"award-number":["F31AG084308"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage\u2010informed framework in which rapid eye movement (REM) sleep\u2010related respiratory events amplify vascular contributions to AD. This framework is unified across four linked lines of evidence suggesting that (1) REM sleep physiology magnifies the hypoxic and hemodynamic burden of OSA, (2) the cardiometabolic consequences of sleep apnea are heightened in REM sleep, (3) REM\u2010related hypoxemia is associated with markers of cerebrovascular pathology, and (4) vascular effects associated with REM\u2010related hypoxemia are associated with medial temporal lobe vulnerability and memory dysfunction: core features of AD. Although direct evidence linking REM\u2010specific OSA to AD biomarkers is lacking, we highlight REM sleep as a potentially critical window through which sleep\u2010disordered breathing may amplify vascular contributions to AD.<\/jats:p>","DOI":"10.1002\/alz.71735","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:05:56Z","timestamp":1786503956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-9666","authenticated-orcid":false,"given":"Destiny E.","family":"Berisha","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Behavior University of California, Irvine  Irvine California USA"},{"name":"Center for the Neurobiology of Learning and Memory University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Benca","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Medicine Wake Forest University  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce A.","family":"Mander","sequence":"additional","affiliation":[{"name":"Center for the Neurobiology of Learning and Memory University of California, Irvine  Irvine California USA"},{"name":"Department of Cognitive Sciences University of California, Irvine  Irvine California USA"},{"name":"Department of Psychiatry and Human Behavior University of California, Irvine  Irvine California USA"},{"name":"Institute for Memory Impairments and Neurological Disorders University of California, Irvine  Irvine California USA"},{"name":"Department of Pathology and Laboratory Medicine University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030780"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.48"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010020\u201002215\u2010w"},{"issue":"3","key":"e_1_2_9_6_1","first-page":"149","article-title":"Obstructive Sleep Apnea: a Growing Problem","volume":"9","author":"Motamedi KK","year":"2009","journal-title":"Ochsner J"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5935\/1984\u20100063.20190081"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00043.2008"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2024.05.040"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.101250"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.12.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(04)00707\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010012\u20100298\u2010z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.01.015"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9904121"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001116"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202411\u20101146OC"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302043280502"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.87.4.432"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104419\u20105692\u20107_50"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy040"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010019\u201001857\u20109"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4306\/pi.2016.13.6.652"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1950"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.6.2597"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406\u20101136OC"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl\u20102015\u2010207231"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsac259"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12707"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010018\u20101727\u20102"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000319"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20100933"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501\u20100046OC"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221121941"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.07.016"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.07.004"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.185"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201033602\u20106"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3618"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001140"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201001051\u2010z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13720"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210183"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.11422"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70280"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000213639"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1607963"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2024"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.111.000091"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201002829\u20104"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201209\u20101654OC"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.09.033"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4986"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18814106"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20982383"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2012.03865.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010006\u20100127\u2010z"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz70855_098573"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy266"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211012109"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.07.009"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16491"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001446\u20103"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1209941"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004373"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010179936"},{"issue":"11","key":"e_1_2_9_69_1","first-page":"14","article-title":"Sex and gender differences in Alzheimer's disease dementia","volume":"35","author":"Mielke MM","year":"2018","journal-title":"Psychiatr Times"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12509"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000534"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2026.0054"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3220\u201014.2014"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.12.025"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf453"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042327"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4213861"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528\u20101167.2008.01681.x"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.12.007"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27538"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71735","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:21:48Z","timestamp":1788668508000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":80,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/alz.71735"],"URL":"https:\/\/doi.org\/10.1002\/alz.71735","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71735"}}