{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:24:03Z","timestamp":1789219443597,"version":"build-2803163510"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54AG054345"],"award-info":[{"award-number":["U54AG054345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alzheimer's &amp; Dementia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the past decade, the Model Organism Development and Evaluation for Late\u2010Onset Alzheimer's Disease (MODEL\u2010AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease. By leveraging human genetic discoveries, MODEL\u2010AD has developed &gt; 70 genetically informed mouse models, standardized phenotyping pipelines, and an open\u2010access data infrastructure aligned with late\u2010onset AD biology. These models incorporate human risk variants, environmental factors, and aging to better capture disease complexity, including emerging recognition of mixed pathologies such as vascular contributions, Lewy body disease, and TDP\u201043 proteinopathy. Despite substantial progress, key challenges remain, including modeling multimorbidity, integrating aging, and improving translational predictability. Here, we outline a strategic roadmap spanning short\u2010, intermediate\u2010, and long\u2010term approaches to refine disease modeling, enhance preclinical testing rigor, and support precision medicine. Continued investment in MODEL\u2010AD will be essential to accelerate therapeutic discovery and establish a scalable framework for studying complex neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/alz.71741","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:39:29Z","timestamp":1786181969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The past, the present, and the future of preclinical mouse models for Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"22","author":[{"given":"Adrian L.","family":"Oblak","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neurosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Radiology and Imaging Sciences, Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sasner","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Carter","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory  Bar Harbor Maine USA"},{"name":"The Jackson Laboratory for Genomic Medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth R.","family":"Howell","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"additional","affiliation":[{"name":"Department of Neurobiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"},{"name":"Aging Institute University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Leal","sequence":"additional","affiliation":[{"name":"Sage Bionetworks  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Territo","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neurosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Medicine, Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Lamb","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Stark Neurosciences Research Institute  Indianapolis Indiana USA"},{"name":"Department of Medical and Molecular Genomics, Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13730"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.735524"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13828"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.886575"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12110"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.03.005"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70501"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.08.681261"}],"container-title":["Alzheimer's &amp; Dementia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/alz.71741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/alz.71741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:21:53Z","timestamp":1788668513000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.71741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/alz.71741"],"URL":"https:\/\/doi.org\/10.1002\/alz.71741","archive":["Portico"],"relation":{},"ISSN":["1552-5260","1552-5279"],"issn-type":[{"value":"1552-5260","type":"print"},{"value":"1552-5279","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71741"}}