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These programs included disruption of glial lipid metabolism and immune pathways at the network level, alongside immune and synaptic alterations coordinated between microglia and oligodendrocytes. Cross\u2010species analyses further revealed that the pathway\u2010level alterations under combined pathology, particularly in immune, lipid, and cell cycle programs, exhibited the strongest concordance with human AD datasets, underscoring their translational relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Beyond benchmarking mouse models, this study provides a high\u2010quality transcriptomic resource to dissect multicellular disease mechanisms in AD and to prioritize therapeutic targets for a network\u2010level systems pharmacology approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/alz.71742","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:47:40Z","timestamp":1786420060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unique 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